Pyroptosis is characterized by the release of pro‐inflammatory cytokines such as IL‐1β and IL‐18, along with the release of damage‐associated molecular patterns (DAMPs) and pathogen‐associated molecular patterns (PAMPs) from dying cells.[77] Within the tumor microenvironment (TME), pyroptotic cells secrete inflammatory cytokines that play critical roles in the initiation and promotion of immune cell infiltration. The gene discussed is IL18; the disease is neoplasm.