Overall, the study revealed that vinburnine is a novel chemotherapeutic agent that increases the sensitivity of NPC to radiotherapy and revealed a novel mechanism by which vinburnine and radiotherapy collaboratively modulate the EDAR‐NFκB‐apoptosis/pyroptosis‐CCL5/CX3CL1 signaling pathway, which provides a promising therapeutic strategy for NPC. The gene discussed is NFKB1; the disease is nasopharyngeal carcinoma.