Inhibiting GSDME‐mediated pyroptosis in NPC cells can result in resistance to docetaxel, contributing to tumor progression.[79] Similarly, the inhibition of caspase‐1 and GSDMD‐mediated pyroptosis induces resistance to paclitaxel in NPC both in vitro and in vivo.[80] Additionally, GSDME is a prognostic factor for NPC, with low expression predicting radiation resistance.[81] Although there have been studies on pyroptosis in NPC, the mechanisms and regulatory factors involved in this process remain unclear. Here, GSDME is linked to nasopharyngeal carcinoma.