Pyroptosis plays an antitumor role in chemotherapy,[4, 5, 6, 7, 8, 9] targeted therapy,[10] and immunotherapy.[11] Unlike apoptosis, pyroptosis involves cellular rupture, with large bubbles forming from the swollen cell membrane, releasing cellular contents, including various inflammatory molecules, which enhance immune cell infiltration and weaken the immunosuppressive effects of the tumor microenvironment, thus activating antitumor immunity.[12, 13] For example, during pyroptosis in tumor cells, GSDME expression increases the phagocytosis of these cells by tumor‐associated macrophages. This evidence concerns the gene GSDME and neoplasm.