GSDME expression increases the sensitivity of radiation‐resistant rectal cancer cells to radiation and induces GSDME‐mediated pyroptosis in CRC cells, enhancing antitumor immunity by promoting the recruitment and activation of NK cells.[14] However, there are few reports on pyroptosis in NPC, and further studies are required to clarify its role in NPC. This evidence concerns the gene GSDME and rectal cancer.