Recently, a single‐cell RNA‐seq study was conducted on ESCC treated with neoadjuvant immunotherapy.[45] The research identified a population of exhausted SPRY1+CD8+ T cells exhibiting features of progenitor exhausted T cells.[45] CD8+Tex‐SPRY1 cells demonstrated the highest number of significant ligand‐receptor interactions with macrophages. The gene discussed is SPRY1; the disease is esophageal squamous cell carcinoma.