To elucidate the complexity of cellular compositions within the tumor microenvironment of ESCC receiving immunochemotherapy, we employed single‐cell RNA‐seq (scRNA‐seq) on unsorted cells derived from CD45‐positive cells in tumors of C57BL/6J mice treated with immunochemotherapy (combo) or vehicle (control) (Figure 2A). The gene discussed is PTPRC; the disease is esophageal squamous cell carcinoma.