Larger tumor diameter at diagnosis was associated with compressive symptoms (OR = 1.07, 95% CI 1.01 – 1.12, p=0.01), optic chiasm compression (OR = 1.17, 95% CI 1.07 – 1.28, p<0.0001), sphenoid sinus invasion (OR = 1.13, 95% CI 1.05 – 1.22, p=0.002), higher PRL levels (β=0.80, p<0.0001), and male sex (β=0.48, p<0.0001). The gene discussed is PRL; the disease is neoplasm.