Analysis of the Nephroseq database revealed that MMP9, HSP90AA1, BCL2, and CYP3A43 were significantly upregulated in CKD, whereas AGTR1, ACE, HNF4A, MMP2, and HMGCR exhibited significant downregulation, with all differences reaching statistical significance (P < 0.05). This evidence concerns the gene HMGCR and chronic kidney disease.