The top 10 hub targets, identified based on degree centrality, included MMP9, BCL2, CYP3A43, ACE, HNF4A, HSP90AA1, AGTR1, MMP2, AGTR2, and HMGCR (Figure 1D), suggesting their pivotal roles in mediating PFAS-induced DKD toxicity. The gene discussed is HSP90AA1; the disease is diabetic kidney disease.