HSP90AA1 and chronic kidney disease: Analysis of the Nephroseq database revealed that MMP9, HSP90AA1, BCL2, and CYP3A43 were significantly upregulated in CKD, whereas AGTR1, ACE, HNF4A, MMP2, and HMGCR exhibited significant downregulation, with all differences reaching statistical significance (P < 0.05).