Analysis of the Nephroseq database revealed that MMP9, HSP90AA1, BCL2, and CYP3A43 were significantly upregulated in CKD, whereas AGTR1, ACE, HNF4A, MMP2, and HMGCR exhibited significant downregulation, with all differences reaching statistical significance (P < 0.05). Here, CYP3A43 is linked to chronic kidney disease.