An early study has shown that activation of FGFR1 can directly phosphorylate LDHA that promotes the Warburg effect and tumor growth by regulating NADH/NAD+ redox homeostasis in human tumor cells [45], and deletion of FGFRs expression does not affect LDHA transcript levels but promotes the degradation of LDHA protein in DU145 cells [46]. This evidence concerns the gene LDHA and neoplasm.