The role of LDHA-aerobic glycolysis in the autocrine FGFs-FGFR1 regulation is further confirmed by the experiments with rescued expression of LDHA in FGFR1-deficient DU145 cells, showing that the rescued LDHA expression in FGFR1-deficient DU145 cells could promote the cell proliferation, migration, and survival from oxidative stress-induced cell death in cultures as well as tumorigenicity of xenografted DU145 PCa in mice. This evidence concerns the gene FGFR1 and posterior cortical atrophy.