FGFR1 and posterior cortical atrophy: All of these studies and our findings from present study suggest a determinant role of FGFR1 signaling in the mechanism of metastasis in advanced PCa and potential of anti-FGFR1 therapies such as anti-FGFR1 antibodies or inhibitors for treatment of advanced PCa after androgen deprivation therapy and AR-targeted therapy.