Differing from differentiated cells that use oxidative phosphorylation or anaerobic glycolysis to metabolize glucose, proliferative tumor cells with growth signals metabolize the glucose specifically by aerobic glycolysis (the Warburg effect) to support rapid cell proliferation [16, 17], and the last step of the aerobic glycolysis, from pyruvate to lactate, is catalyzed by lactate dehydrogenase A (LDHA) [18]. The gene discussed is LDHA; the disease is neoplasm.