Unlike other common PCa cell lines (e.g., PC3 and LNCaP), monolayers of DU145 constitutively secrete FGF2 and express functional FGFR1 protein that can respond to exogenous FGF2 and the heparin-binding fractions of DU145 cell extracts [26–28], indicating that the growth of DU145 cells is at least in part regulated by the autocrine FGF/FGFR1 signaling, a unique model for investigating the role of the autocrine FGFs/FGFR1 in the growth of advanced PCa. The gene discussed is FGF2; the disease is posterior cortical atrophy.