Indeed, in an ARR2PBiPbsn−Cre/TRAMP/fgfr1loxP/loxP transgenic mouse model of PCa, tumors that escape fgfr1 deletion or express fgfr1 are poorly differentiated and metastatic phenotype, whereas those with fgfr1 deletion are well-differentiated and phyllode phenotype [15]. This evidence concerns the gene FGFR1 and posterior cortical atrophy.