FGF2 and prostate neoplasm: Indeed, in prostate tumor tissues, upregulated expression of FGFs including FGF2 as paracrine/or autocrine growth factors for PCa cells, and their receptor FGFRs such as FGFR1 are positively correlated with PCa progression [12, 38, 39], suggesting that FGFs/FGFRs systems might be an important autocrine regulator for PCa cell growth.