FGF2 and prostate neoplasm: There are increased levels of FGF1, FGF2, FGF6, and FGF8 expression in prostate tumor tissues as paracrine and/or autocrine growth factors for tumor growth, and expression of FGFRs, and particularly FGFR1, is most closely linked to PCa progression as well as to castration-resistant PCa (CRPC) bone metastases or to less favorable disease-specific survival in CRPC [10–14].