The present study has shown that knockdown of FGFR1 expression in DU145 cells results in reducing cell proliferation, migration, and survival from H2O2-induced cell death, which is associated with reduction of LDHA expression, lactate production, and extracellular acidification, the measures of aerobic glycolysis in tumor cells [18]. The gene discussed is FGFR1; the disease is neoplasm.