FGFR1 and posterior cortical atrophy: Our data further confirm that the aerobic glycolysis in AR-independent PCa DU145 cells can be regulated by autocrine FGFs-FGFR1 signaling via LDHA, and it mainly contributes to their proliferation, migration, and survival in cultures as well as tumorigenicity in a xenograft model, suggesting that targeting key metabolic control points of aerobic glycolysis, such as FGFRs or LDHA, might warrant investigation as potential drug target candidates for CRPC.