LDHA and prostate neoplasm: First, in addition to autocrine FGFs/FGFRs, other autocrine growth factor/their receptor loops such as VEGF/VEGFR2 and TGFα/EGFR may contribute the growth of DU145 cells [55], so that the contribution of these autocrine growth systems to the LDHA-aerobic glycolysis in this cell line or other prostate tumor cells remains further investigation.