Our data further confirm that the aerobic glycolysis in AR-independent PCa DU145 cells can be regulated by autocrine FGFs-FGFR1 signaling via LDHA, and it mainly contributes to their proliferation, migration, and survival in cultures as well as tumorigenicity in a xenograft model, suggesting that targeting key metabolic control points of aerobic glycolysis, such as FGFRs or LDHA, might warrant investigation as potential drug target candidates for CRPC. This evidence concerns the gene AR and posterior cortical atrophy.