Third, the present study shows the autocrine FGFs/FGFR1 signaling facilitates cell proliferation, migration, and survival of DU145 cells via LDHA-aerobic glycolysis, but if FGFRs such as FGFR2 on tumor cells of CRPC in PCa patients can be activated by FGFs by paracrine and endocrine mechanisms and lead to the progression of PCa through the Warburg effect are not investigated. The gene discussed is FGFR1; the disease is neoplasm.