As a part of the Commander complex, FAM45A dysfunction may indirectly affect endocellular trafficking processes associated with Ritscher-Schinzel, a multisystem developmental disorder characterized by abnormal craniofacial features as well as cerebellar hypoplasia, thus playing a role in the development of the disease (Laulumaa et al., 2024; Healy et al., 2023). The gene discussed is DENND10; the disease is Cerebellar hypoplasia.