Additionally, ‘Pleckstrin homology domain-containing family M member 1’ (Plekhm1) interacts with Rab7 to regulate vesicular trafficking in osteoclasts, and its mutations (e.g., in Y949–R954/L1011–I1018 regions) disrupt lysosomal transport and cause osteosclerosis via NDE1/NDEL1-related pathways (Das et al., 2024; Van Wesenbeeck et al., 2007). The gene discussed is PLEKHM1; the disease is osteosclerosis.