PLEKHM1 and osteosclerosis: Rab7 role in lysosomal transport is further modulated by its interaction with Plekhm1 (Ng et al., 2019), whose mutations are linked to osteosclerosis (Sobacchi et al., 2013); Plekhm1 deficiency disrupts lysosomal anchoring to microtubules, impairing bone resorption (Fujiwara et al., 2016).