PNPLA3 and hepatocellular carcinoma: Compared with individual SNPs, although no statistically significant difference was observed in the AUC for the GRS and PNPLA3 in MASLD-related HCC and cirrhosis development (Table S6), the OR for GRS 6–8 was substantially higher than that for PNPLA3 (3.603 vs. 2.805 or 176.0 vs. 13.81 for cirrhotic HCC, and 13.12 vs. 6.873 for cirrhosis).