PNPLA3 and Cirrhosis: At an individual level, only PNPLA3 GG genotype was associated with a significantly increased risk of MASLD-related HCC (odds ratio [OR]: 2.805, 95% CI: 1.083–7.264, p = 0.034) and cirrhosis (OR: 6.873, 95% CI: 3.293–14.35, p <0.001).