Patients with cirrhosis (n = 242) and the PNPLA3-GG genotype showed a 2.8-fold increase in the odds of developing cirrhotic HCC compared with those with the CC genotype (OR: 2.805, 95% CI 1.083–7.264, p = 0.034, Table 2). Here, PNPLA3 is linked to hepatocellular carcinoma.