For example, sEVs secreted by M2 macrophages promote the conversion of macrophages toward the M2 phenotype in viral myocarditis (48), while sEVs secreted by ischemic cardiomyocytes act on macrophages, modulating their inflammatory cytokine expression profile and enhancing their adhesion to fibronectin (49). The gene discussed is FN1; the disease is viral myocarditis.