CD4 and tuberculosis: To further characterize CD4 T cells during TB and with or without T2D, we analyzed their maturation states based on CCR7 and CD45RA expression, with classification into naïve (CCR7+CD45RA+), central memory (CM: CCR7+CD45RA-), effector memory (EM: CCR7-CD45RA-), and terminally differentiated memory (TEMRA: CCR7-CD45RA+) T cells (25, 26, 29).