Taken together, our analysis has revealed that T2D differentially alters distinct features of circulating T cells in people with TB, including maturation, proliferation, differentiation, and the activation of Mtb antigen-responsive CD4 T cells, despite similar cytokine responses of Mtb-responsive CD4 T cells in TB patients with or without T2D. The gene discussed is CD4; the disease is type 2 diabetes mellitus.