CD47 and central nervous system cancer: High surface density of the “don’t-eat-me” ligand CD47 on glioma stem-like cells, together with abundant signal-regulatory-protein-α on neighbouring microglia, limits synapse formation and debris clearance; ex vivo-expanded human macrophages regain phagocytic capacity after exposure to the anti-CD47 monoclonal antibody magrolimab, and intra-tumoural delivery of a CD47-blocking peptide augments antigen cross-presentation and synergises with PD - 1 blockade in orthotopic models (48–50).