PCT, procalcitonin; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; IL-6, interleukin-6; WBC, white blood cell count; THR, total hip replacement; CABG, coronary artery bypass grafting; MODS, multiple organ dysfunction score; AUC, area under the curve; SSI, surgical site infection; UTI, urinary tract infection; AKI, acute kidney injury; ICU, intensive care unit; SIRS, systemic inflammatory response syndrome; PJI, periprosthetic joint infection; hsCRP, high-sensitivity C-reactive protein. The gene discussed is CRP; the disease is systemic inflammatory response syndrome.