Coagulopathy is the main pathogenic factor in MVT, although in 20% of cases no specific cause is identified. Conditions such as malignancies, inflammatory diseases, and antiphospholipid syndrome can lead to hypercoagulability, while inherited disorders like Factor V Leiden mutation or deficiencies of protein C or protein S may result in thrombophilia [11,12]. This evidence concerns the gene PROS1 and Rare hereditary thrombophilia.