For instance, the upregulation of Cav3.2, associated with absence seizures in epilepsy,24 would have the primary effect of increasing the amplitude of the burst curve around −65mV (Figure 4I), due to an increase in the magnitude of the overall T-type Ca current around that voltage range (Figure 4A), explaining the hyperexcitability and enhanced burst firing associated with absence seizures. This evidence concerns the gene CACNA1H and epilepsy.