,34,35 From a translational perspective, developmental disruptions in the expression of risk genes, particularly those highly expressed in the TRN and associated with disorders like schizophrenia (e.g., Cav3.3), could potentially alter the balance of Ecel1-like and Spp1-like neurons, impacting spindle generation through broader transcriptional changes. The gene discussed is SPP1; the disease is schizophrenia.