Microvessel density(MVD) is the gold standard for assessing tissue angiogenesis (3), Vascular Endothelial Growth Factor(VEGF) is a key regulator of tumor microangiogenesis (4), Ki67 and PCNA can reflect the proliferative activity of tissues (2), which are closely related to tumor aggressiveness, metastasis and prognosis (5). The gene discussed is MKI67; the disease is neoplasm.