Dyslipidemia promotes lipid uptake through the aberrant expression of LDL receptors (LDLR) and syndecan-1 on MM cells, while obesity-induced BMA remodeling inhibits apoptosis and exacerbates osteolytic lesions via the secretion of leptin and resistin (11). The gene discussed is RETN; the disease is obesity due to melanocortin 4 receptor deficiency.