Building upon these findings, our research team previously developed a clinical prognostic risk model based on lipid storage-related genes, identifying AUP1 (Ancient Ubiquitous Protein 1), a lipid droplet regulator involved in VLDL assembly, as a key player in ccRCC progression through its induction of lipid accumulation (10). This evidence concerns the gene AUP1 and nonpapillary renal cell carcinoma.