When sepsis involves the circulatory system, it can induce or exacerbate cardiac dysfunction (i.e., sepsis-associated cardiac dysfunction, refers to newly emerging reversible heart failure during the course of sepsis, characterized by a decrease in left ventricular ejection fraction (LVEF < 50%) or elevated cardiac injury markers (cTnI > 0.4 ng/ml), and must exclude patients with chronic heart failure), creating a critical state with complex pathophysiological mechanisms and a very poor clinical prognosis (3, 4). The gene discussed is TNNI3; the disease is Sepsis.