This was followed by the hippocampal BBB that presented a sex-dependent alteration of caveolin-1 expression and higher expression of β-dystroglycan in astrocyte endfeet with age (Table 3 and Supplementary Table 1), and surprisingly, despite the high sensitivity of white matter to age-associated cerebral small vessel disease,42 we observed no differences in the corpus callosum BBB (Table 3). This evidence concerns the gene CAV1 and cerebral small vessel disease.