Moreover, NfL increases with disease progression and correlates with striatal atrophy.22,23 In genetic ataxias as Spinocerebellar ataxia type 3 (SCA3), NfL concentrations increase with disease severity and positively correlate with SARA score, while in other type of SCAs, such as SCA1, SCA2 and SCA7, correlation between NfL and disease status was not observed.6 The gene discussed is ATXN7; the disease is Spinocerebellar ataxia type 3.