However, in IBS, this normally balanced structure of cell function can be disrupted by perturbations in the gut microbiome and chronic low-grade inflammation, potentially impacting the concentration of CgA cells.15 Based on the hypothesis that altered CgA cell density may represent a novel feature of IBS, this study aimed to evaluate and summarize the differences in CgA concentration between individuals with IBS and healthy controls. The gene discussed is CGA; the disease is irritable bowel syndrome.