Although CgA cell densities remained unaltered in patients with IBS, changes in specific endocrine cells should not be ruled out, as serotonin cells change in the rectum of patients with IBS.29 The different results of the colon and rectum can be explained by the physiological differences where the rectum’s only purpose is to preserve the feces before it is expelled, while the colon absorbs the water, salt, and several fat-soluble vitamins.12 This evidence concerns the gene CGA and irritable bowel syndrome.