ACE2 and COVID-19: Meanwhile, Davidov-Derevynko et al showed that liver aminotransferase elevation is more predominant than ALP increment in their sample of 382 patients, suggesting a hepatocellular pattern of liver damage as opposed to a cholestatic one.28 Although angiotensin-converting enzyme 2 (ACE-2) is highly expressed in bile duct cells, which indicates a potential for liver injury due to cholangiocyte dysfunction in patients with COVID-19,32 our study found no significant difference in ALP levels among the three groups, with a P value of 0.191.