HLA-G and Crohn disease: However, studies have explored the role of HLA-G in other inflammatory diseases like Crohn’s disease.19 So, HLA-G could be useful in predicting the risk of complications such as Barrett’s esophagus and esophageal adenocarcinoma, used as a biomarker for identifying patients who may be at higher risk for these complications, which could aid in surveillance and early intervention strategies.