Migraine had no association with 24 diseases (AF, hemorrhagic, ischemic stroke, stroke, myocardial infarction, insomnia, difficulty awakening, celiac disease, inflammatory bowel disease, psoriasis, T1D, T2D, frontotemporal dementia, Lewy body dementia, MS, vascular dementia, AR, asthma, RA, SLE, MD, and PD), 5 physiologic factors (IGF-1, higher serum vitamin D levels, ICV, WMLs, and gut microbiota). The gene discussed is IGF1; the disease is insomnia.