Chengcheng Zhang et al. (72) identified 21 druggable genes significantly associated with migraine (BRPF3, CBFB, CDK4, CHD4, DDIT4, EP300, EPHA5, FGFRL1, FXN, HMGCR, HVCN1, KCNK5, MRGPRE, NLGN2, NR1D1, PLXNB1, TGFB1, TGFB3, THRA, TLN1, and TP53), two of which were significant in both blood and brain (HMGCR and TGFB3). Here, CDK4 is linked to migraine disorder.