Overall, regarding migraine, migraine was a risk factor for 3 diseases (AD, CeAD, and VTE) and a protective factor for 3 diseases (CAD, angina, and LAS), 3 behavioral habits factors (delayed AFS, more physical activity, and maternal smoking), 1 dietary intake factors (more alcohol consumption), 3 physiologic factors (higher IL-2, BMI, and serum vitamin D level). This evidence concerns the gene IL2 and Alzheimer disease.