Kang Qu et al. (68) indicated that HMGCR expression (OR = 1.55, 95% CI: 1.30–1.84, p = 6.87 × 10−7) and the circulating levels of three lipids (LDL-C, APOB, and TC) adjusted by HMGCR expression (OR = 1.55, 95% CI: 1.30–1.84, p = 6.87 × 10−7) were significantly associated with an increased risk of migraine (LDL-C: OR = 1.51, 95% CI 1.21–1.88, p = 2.50 × 10−4; APOB: OR = 2.12, 95% CI: 1.56–2.87, p = 1.35 × 10−6; TC: OR = 1.63, 95% CI: 1.30–2.06, p = 2.93 × 10−5). Here, HMGCR is linked to migraine disorder.