Six diseases (VTE, breast cancer, insomnia, difficulty awakening, MDD, and depression), 2 behavioral habits factors (watching TV, smoking initiation), and 11 physiologic factors (higher FVIII activity, vWF levels, phosphorylated fibrinopeptide A level, HGF, SBP, DBP, PP, elevation of calcium level by 1 mg/dL, ITIH1, SREBF2, and LachnospiraceaeUCG001) were risk factors of migraine. The gene discussed is F8; the disease is major depressive disorder.