Three behavioral habits factors (delayed AFS, more years of schooling, and physical activity), 4 dietary intake factors (more alcohol consumption, coffee consumption, cheese intake, and salad intake), and 13 physiologic factors (higher fibrinogen levels, APTT, serum vitamin D level, IGF-1, SA, HV, neuralized E3 ubiquitin-protein ligase 1, LRP11, ADGRF5, APO-A1, REV1, ICV, and BMI) were protective factors of migraine. This evidence concerns the gene REV1 and migraine disorder.