IGF1 and migraine disorder: MR analysis showed no significant causal relationship between migraine and insulin-like growth factor 1 (IGF-1) levels or higher serum vitamin D levels (OR = 1.00, 95% CI: 0.97–1.02) (OR = 0.98, 95% CI: 0.97–1.00); there is a heightened risk of migraines and diminished levels of interleukin-2 (IL-2) levels (OR = 0.01, 95% CI: 0.00–0.09) (Figure 7A).