Chengcheng Zhang et al. (72) identified 21 druggable genes significantly associated with migraine (BRPF3, CBFB, CDK4, CHD4, DDIT4, EP300, EPHA5, FGFRL1, FXN, HMGCR, HVCN1, KCNK5, MRGPRE, NLGN2, NR1D1, PLXNB1, TGFB1, TGFB3, THRA, TLN1, and TP53), two of which were significant in both blood and brain (HMGCR and TGFB3). This evidence concerns the gene PLXNB1 and migraine disorder.