F8 and major depressive disorder: Three diseases (VTE, SLE, and MDD) and 3 physiologic factors (higher FVIII activity, vWF levels, and phosphorylated fibrinopeptide A) were risk factors of MWA; 1 behavioral habits factor (delayed AFS), 1 dietary intake factor (more coffee consumption), and 2 physiologic factors (fibrinogen levels and APTT) were protective factors of MWA.