TP53 and neoplasm: In oncology, SNVs in key genes such as epidermal growth factor receptor (EGFR), tumor protein 53 (TP53), Kirsten rat sarcoma viral oncogene homolog (KRAS), breast cancer susceptibility gene 1 (BRCA1), BRCA2, and B-Raf proto-oncogene (BRAF), have been shown to influence tumor biology and therapeutic response.