GCK and diabetes mellitus: Moreover, LBP downregulated the expressions of glucose-6-phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK) to inhibit gluconeogenesis, while upregulated the expressions of glucokinase (GK), phosphofructokinase 1 (PFK1) and pyruvate kinase (PK) to activate glycolysis via the AMP-activated protein kinase (AMPK) signaling pathway in DM mice.