In this study, Wenxin Keli can not only increase the expressions of PPARα and PPARδ in rats with heart failure after myocardial infarction but also promote the expressions of CPT-1α, CD36, and GLUT4, indicating that Wenxin Keli can regulate fatty acid metabolism and improve the utilization rate of glucose in the mechanism of treating heart failure. Here, PPARD is linked to heart failure.