Since PGC-1α interacts with various coactivator nuclear receptors, such as PPARs and ERRs, to regulate mitochondrial oxidative metabolism (Vannuchi and Pisani, 2025; Fan and Evans, 2015), the reduced interaction between PGC-1α and PPARs and ERRs after heart failure negatively affects fatty acid oxidation and glucose uptake (Vannuchi and Pisani, 2025; Cantó and Auwerx, 2009). The gene discussed is PPARGC1A; the disease is heart failure.