In this study, Wenxin Keli can not only increase the expressions of PPARα and PPARδ in rats with heart failure after myocardial infarction but also promote the expressions of CPT-1α, CD36, and GLUT4, indicating that Wenxin Keli can regulate fatty acid metabolism and improve the utilization rate of glucose in the mechanism of treating heart failure. The gene discussed is PPARA; the disease is myocardial infarction.