NR1H3 and Sepsis: Given the significant roles of alveolar macrophages in ALI (Cheng et al., 2021; Kumar, 2020) as well as the discovery that LXRα was highly expressed in macrophages and was closely associated with autophagy, as demonstrated by bioinformatics methods using online databases, we hypothesize that LXRα may regulate sepsis-induced lung injury through autophagy.