It is well known that LXRs, which are classified into LXRα and LXRβ subtypes, play important roles in various pulmonary diseases, including lung inflammation, asthma, ALI, and pulmonary fibrosis (Hernández-Hernández et al., 2024; Zhang et al., 2021; Yan et al., 2025; Shichino et al., 2019). Here, NR1H3 is linked to acute respiratory distress syndrome.