NR1H3 and Sepsis: In the present study, we performed bioinformatics analysis on a database and found that LXRα was distributed mainly in the macrophages, epithelial cells, and fibroblasts and was closely associated with autophagy (Figure 2); therefore, we selected macrophages to explore the mechanisms by which LXRα regulates sepsis-related lung injury by regulating macrophage autophagy.