EGFR and cancer: Indeed, this model is very well-documented in the literature and proven to promote NP capture by cancer cells.14 Despite the fact that HNC cell lines are reported to express high levels of αvβ3 and αvβ5 integrins, known to allow binding to the RGD motif, a low amount of @D + cRGD IONPs was internalized by our FaDu and 93-VU cell lines.15 For the FaDu cell line, this may be explained by the fact that these cells would not express αvβ3 integrins.27 Consequently, another IONP model was synthesized using P22 for @D IONP vectorization to the EGFR.