EGFR and neoplasm: Yang and his colleagues showed that the use of macrophages as a transporter allows for better diffusion of NPs within hypoxic tumor tissue.33 In this context, it should be important to investigate the capacity of macrophages to internalize and transport IONPs, based on our previous work.34 To conclude, our IONP model vectorized with P22 seems to be appropriate to achieve internalization in HNC cell lines overexpressing EGFR.