Hibiscus prevented memory impairment, and this can be attributed to STZ‐induced improvement in neuroinflammation and amyloidogenesis. Consequently, hibiscus represents a safe and promising agent that can be repurposed for AD (Alzheimer's disease) through the exercise of anti‐inflammatory, anti‐acetylcholinesterase, antioxidant, and anti‐amyloidogenic activities. The gene discussed is ACHE; the disease is memory impairment.