Several potential candidates have been proposed, including TREM-like transcript-2 (TLT-2), IL20Rα and phospholipase A2 receptor 1 (PLA2R1), but the precise mechanisms of action of these receptors are unclear, and the current evidence does not fully elucidate the complex effects of B7-H3 on tumour behaviour and the TME [20,21]. This evidence concerns the gene TREML2 and neoplasm.