CD276 and head and neck squamous cell carcinoma: In the area of epigenetics, the small molecule inhibitors JQ1 and Ibet-151 have demonstrated the ability to inhibit the activity of BET (Bromodomain and Extra Terminal domain) proteins, thereby impeding the function of the B7H3 super-enhancer and dampening the expression levels of B7H3, as well as inhibiting the proliferation of HNSCC [78].