BDNF and ischemia: This is supported by: (i) Emodin promotes axonal regeneration via BDNF upregulation, potentially underpinning its role in stroke recovery [11]; (ii) The critical window for infarct volume determination occurs within 24–48 h post‐ischemia, whereas functional/behavioral recovery relies on neuroplasticity—a process spanning weeks and often independent of acute infarct volume.