TNF and early-onset autosomal dominant Alzheimer disease: KEGG enrichment analysis revealed that these targets are closely related to lipid and atherosclerosis, the PI3K‐Akt, MAPK, IL‐17, and the TNF signaling pathways, Alzheimer's disease, apoptosis, pathways of neurodegeneration involving multiple diseases, and the neurotrophin signaling pathway (Figure 6D).