SNAP25 and Alzheimer disease: A previous study reported that CSF synaptosomal-associated protein 25 (SNAP-25), another biomarker of presynaptic dysfunction (Camporesi et al., 2020), moderated the association between axonal injury and temporoparietal gray matter (Saloner et al., 2022), suggesting that differential levels of synaptic dysfunction may be a pathogenic driver of atrophy in AD-related brain regions; however, that study did not assess cognitive outcomes.