Through network propagation analysis of significant DEGs in PD vs. MSA-P, we identified upregulated genes in PD (PD > MSA-P) that are associated with mitochondrial function (NUDT8, MTCH2) and cellular stress response (YWHAQ, YWHAG, CALM1) (Fig. 4E). The gene discussed is MTCH2; the disease is multiple system atrophy.