TG and central nervous system cancer: A multi-target network integrating these pathways was constructed in Cytoscape 3.8.2 (Fig. 6G), while chord plots (Fig. 6F) visualized interactions among five core pathways: Focal adhesion (mechanotransduction and neuronal survival), FoxO signaling (oxidative stress regulation), Thyroid hormone signaling (metabolic modulation), Prostate cancer (cell proliferation control), Glioma signaling (glia-neuron crosstalk).