SH3BP5 and diffuse large B-cell lymphoma: Additionally, SH3BP5 expression positively correlated with mitochondrial OXPHOS components (e.g., Complexes I, II, IV, and V) and regulators of mitochondrial dynamics (such as cardiolipin synthesis, fission, organelle contact sites, and mitophagy) (Fig. 4G), further reinforcing its dual role in supporting both the immunosuppressive TME and the bioenergetic demands of OXPHOS-dependent DLBCL.