One patient with GCB-like DLBCL showed mutations in EZH2, KMT2D and CREBBP most consistent with the EZB/C3 subtype in nodal DLBCL [12]; this patient was in ongoing complete remission after treatment with R-CHOP at last follow-up (128 months). The gene discussed is EZH2; the disease is diffuse large B-cell lymphoma.