Using summary statistics of all available GWAS, the Human Genetic Evidence guidelines (HuGE) tool calculates a Bayes Factor of 45 × 5−8, concluding that there is very strong evidence for the involvement of variants located in this gene (eQTL and tagger variants for XBP1 expression) with T2DM risk in humans (Supplementary Fig. 7)50. This evidence concerns the gene XBP1 and type 2 diabetes mellitus.