β-catenin, a key regulator of osteogenic differentiation, fracture repair, and osteoporosis, plays a crucial role in these processes.24 Recent studies have indicated that Piezo1 promotes osteogenesis through the Wnt/β-catenin signaling pathway and accelerates bone defect healing by enhancing the coupling of osteogenesis and angiogenesis.25 To investigate whether β-catenin interacts with Lars2 in the context of Piezo1 regulation, we retrieved the protein structures of CTNNB1 (β-catenin) and Lars2 from the UniProt database and studied their interactions using Hdock. This evidence concerns the gene PIEZO1 and osteoporosis.