Lars2 is mainly located in mitochondria and plays a crucial role in regulating mitochondrial function by influencing mitochondrial gene translation processes, which are essential for cell differentiation.41 In myoblasts, the abnormal expression of Lars2 can significantly reduce cellular ATP levels and impair maximal and basal respiration, as indicated by a decrease in OCR.18 In patients with colorectal cancer, elevated levels of Lars2 lead to significant abnormalities in mitochondrial metabolism, particularly in NAD+ regeneration. This evidence concerns the gene LARS2 and colorectal cancer.