ITGAE and Alzheimer disease: Fig. 1f–l), where Arm A of the trajectory plot was populated by a lower proportion of CD103+CD8+ Trm cells in 3xTg-AD mice compared to WT controls (WT = 26.1%, 3xTg-AD = 14.9%) accompanied by a higher percentage of CD103–CD8+ Trm cells in Arm B (WT = 54.5%, 3xTg-AD = 75.8%; Fig. 3c; Supp.