Finally, our analysis of a published dataset showed that ITGAL (encoding the CD11a subunit of LFA-1) was upregulated in the whole population of circulating CD8+ T cells in AD, suggesting that the LFA-1–ICAM-1 and CXCR3–CXCL10 axes may act in concert to promote the invasion of the brain by peripheral CD8+ T cells in AD. Here, CD8A is linked to Alzheimer disease.