CD69 and Alzheimer disease: We observed a dramatic increase in both the proportion and absolute numbers of CD69+CD103– Trm cells in the brains of 6-month-old 3xTg-AD mice compared to sex/age-matched WT controls (WT proportion = 48.025%, 3xTg-AD = 88.08%; WT number = 6,224.72, 3xTg-AD = 12,760.5), with CD69+CD103+ Trm cells showing the opposite profile (Fig. 3d, e).