CXCR3 was recently shown to regulate CD8+ T cell infiltration and neuronal damage in a human 3D model of neuro-immune interactions, and CXCL10 (the chemokine ligand of CXCR3) accumulates in AD, suggesting that the trafficking of detrimental CD8+ T cells in the AD brain is mediated by CXCR3–CXCL10 interaction57. Here, CD8A is linked to Alzheimer disease.