In this context, our data show that the co-occurrence of Aβ and tau pathologies significantly reduces the abundance of intraparenchymal CD103+CD8+ Trm cells in the brains of 3xTg-AD mice compared to WT animals due to the downregulation of genes encoding transcription factors and cytokines involved in the differentiation and maintenance of CD103+ Trm cells31. This evidence concerns the gene CD8A and Alzheimer disease.