MAPT and Alzheimer disease: These data were confirmed by ELISA experiments, showing significantly less Aβ1-40 and Aβ1-42 deposition, and tau hyperphosphorylation (pT231, AT180) in the soluble and insoluble fractions of brain homogenates from 3xTg-AD mice depleted of CD8 + T cells compared to isotype controls (Fig. 5j, k), while no significant differences were observed in the levels of total tau (Fig. 5l).