We observed a significant decrease in both the Aβ load and levels of tau hyperphosphorylation in the hippocampus of 3xTg-AD mice following the depletion of circulating CD8+ T cells compared to animals treated with an isotype control (Fig. 5g, h), whereas the levels of total tau were unchanged (Fig. 5i). The gene discussed is CD8A; the disease is Alzheimer disease.