Neuropathological studies showed a significantly lower Aβ load and significantly less tau hyperphosphorylation (AT180) in the brains of 3xTg-AD/Itgal–/– mice compared to sex- and age-matched 3xTg-AD controls, but no significant difference in the levels of total tau (Fig. 6d–f). This evidence concerns the gene ITGAL and Alzheimer disease.