The Trm marker CD103 (αE integrin) is also more abundant in the 5xFAD mouse model, which develops an early and aggressive amyloid pathology, together with higher levels of CXCR6 and PD-1 compared to WT controls, and this CD8+ T cell subset has a protective anti-Aβ role suppressing the activation of microglia13. This evidence concerns the gene CD8A and amyloidosis.