SIRPA and neoplasm: To determine whether some of the effects of SHP2 inhibition on macrophage morphology are cell-autonomous (e.g., might occur before interaction with tumor cells), we treated BMDM (Iba1+;CD172a+) for 8 h with vehicle or SHP2 inhibitor; SHP2 inhibition increased the small, round morphology (Cluster 4) versus vehicle (Fig S5I–K).