WNK2 and gastric adenocarcinoma: For example, in gastric adenocarcinoma, upregulation of SLC39A10 enhanced intracellular Zn2+ levels, thereby activating casein kinase 2 and its downstream mitogen-activated protein kinase/extracellular signal–regulated kinase and PI3K/AKT pathways, ultimately promoting tumor proliferation and progression (46).