INHBB encodes a subunit of the dimeric activin and inhibin protein complexes and has been shown to influence skeletal muscle mass in mice.62,63 In human adipose tissue, it is downregulated during diet-induced weight loss and correlated with metabolic syndrome risk factors.64 Furthermore, INHBB has recently been approved as a drug target for pulmonary arterial hypertension.83 Many of the colocalized genes identified here may represent promising therapeutic targets. Here, INHBE is linked to metabolic syndrome.