PCK2 and type 2 diabetes mellitus: One example colocalized gene, PCK2, was the fourth closest gene to the relevant T2D signal but is a compelling candidate gene for T2D, due to its role in skeletal muscle development and its involvement in glucose homeostasis through the stimulation of insulin release.82 By leveraging a larger sample size and conditional modeling, we enhanced the resolution and sensitivity of eGene and regulatory variant discovery, improving our ability to link GWAS signals to putative causal genes and regulatory elements in skeletal muscle.