RUNX1 and acute myeloid leukemia: To validate that these MECOM-regulated cisRE and gene networks that were conserved across multiple AML models, we performed GSEA of these MECOM-regulated cisRE and gene networks in UCSD-AML1-dTAG and HNT-34-dTAG cells and showed a strong enrichment of both networks in cells treated with dTAGV-1 vs dimethyl sulfoxide via bulk RNA-seq and ATAC-seq (supplemental Figure E-L).