MECOM and acute myeloid leukemia: Notably, far more MECOM down genes show significantly reduced expression at 24 hours vs 6 hours after MECOM degradation (58 genes vs 1 gene, respectively, L2FC less than –0.5; P < .001; supplemental Figure 2A-D), highlighting how the loss of stem cell maintenance gene programs in AML is likely to be secondary to the activation of myeloid differentiation programs observed upon the acute loss of MECOM.