RUNX1 and acute myeloid leukemia: ,22 We selected the AML cell lines MUTZ-3, UCSD-AML1, and HNT-34 cells, considering their high MECOM expression level and cytogenetic status that arises due to an oncogenic translocation/inversion event that juxtaposes an enhancer of GATA2 to drive high-level MECOM expression.23