To directly elucidate MECOM-driven transcriptional and epigenetic programs in stem cell–like leukemia cells, we engineered 3 AML cell line models with a 2xHA-FKBP12F36V-P2A-enhanced green fluorescent protein (eGFP) cassette at the C-terminus of the endogenous MECOM locus (Figure 1A). This evidence concerns the gene MECOM and leukemia.