It is released abundantly after infection and tissue damage to regulate the entire pathological process of inflammatory response, thereby maintaining internal and external balance of the body.[31] Research has confirmed that IL-6 activates PSCS through paracrine and autocrine pathways, promoting the progression of pancreatic fibrosis.[32] As is well known, an important histopathological feature of CP is pancreatic fibrosis. Here, IL6 is linked to infection.