POSTN and lung adenocarcinoma: Furthermore, a univariate Cox regression analysis was performed to assess the association of gender, age, disease stage, and POSTN with lung adenocarcinoma recurrence (Fig 5A), revealing significant associations between stage II (Odds Ratio [OR], 3.531; P < 0.001) and high POSTN expression (OR, 2.042; P < 0.001) with postoperative recurrence.