Among these core targets, EGFR (48-sided), CASP3 (47-sided), ESR1 (42-sided), HSP90AA1 (42-sided), SRC (42-sided) and IGF1 (40-sided) have high nodes, indicating that they are closely associated with PA anti-osteosarcoma dense mechanisms. Here, CASP3 is linked to osteosarcoma.