Within the context of preeclampsia, studies of SERPINE2 expression have been mixed e.g. Chelbi et al. (2007) (Chelbi et al. 2007) reporting that hypoxia induced the expression of SERPINE2, whereas Sheridan et al. (2019) (Sheridan et al. 2019) reported upregulation of SERPINE2 in the absence hypoxia. The gene discussed is SERPINE2; the disease is preeclampsia.