Regarding the relationship between biological profile and aging, as shown in Table 2, age strongly correlated with neurofilament CSF levels, both light and heavy chains (respectively r = 0.626 and r = 0.533, p < 0.001), with YKL-40 (r = 0.4, p < 0.001) and AD-related pathology biomarkers, in particular with tau species (p-Tau r = 0.317 and t-Tau r = 0.293, p < 0.001) (Table 2, Fig. 2). Here, CHI3L1 is linked to Alzheimer disease.