In a retrospective analysis of IDH-wildtype rGBM, we used Cox regression to evaluate prognostic factors including age, sex, Ki-67 index, Karnofsky Performance Status (KPS), time to first progression, number of recurrent lesions, tumor location, O6-methylguanine-DNA methyltransferase (MGMT) methylation status, and post-recurrence treatment. This evidence concerns the gene MKI67 and neoplasm.