Multivariate analysis revealed KPS > 50 (p = 0.009; HR 0.61, 95% CI: 0.42–0.88), MGMT methylation (p = 0.033; HR 0.68, 95% CI: 0.48–0.97), time to first recurrence >12 months (p = 0.048; HR 0.69, 95% CI: 0.47–1), single lesion (p = 0.005; HR 0.63, 95% CI: 0.46–0.87), and post-recurrence therapy (surgery: HR 0.35, 95% CI: 0.21–0.59; targeted therapy/Tumor-treating fields (TTF)/re-irradiation: HR 0.5, 95% CI: 0.35–0.71; both p < 0.001) were favorable independent prognostic factors for OS. Here, MGMT is linked to neoplasm.